The role of nasal microbiome in Parkinson's disease Microbiome Parkinsons Disease nasal nose TrendsNeuro institutpasteur univ_paris_cite Chu_Gpe
By Dr. Priyom Bose, Ph.D.Sep 5 2022Reviewed by Benedette Cuffari, M.Sc. Billions of microorganisms, including bacteria, fungi, and archaea, are present in the human nose, which collectively form the nasal microbiome.
Composition of the nasal microbiome Among the different microorganisms that are present in the nose, bacteria are considered the main component. Although 104 different strains of bacteria are present in the nose, only two to ten species make up 90% of an individual’s nasal microbiome. Most of the bacterial strains are symbiotic; however, some opportunistic pathobionts are also present that may cause various illnesses.
The role of the nasal microbiome in olfaction Several studies have indicated that the nasal microbiota limits pathogenic colonization and modulates host-immune responses associated with respiratory tract infections and disease severity. However, a limited number of studies related to the role of the nasal microbiome in olfactory performance have been conducted.
To determine whether nasal microbiota impacts human olfaction, 18 to 46-year-old individuals in a previous study were classified into three groups: good, normal, and poor sense of smell. This study revealed that although a similar nasal microbial population was present in all groups, the presence of butyric-acid-producing bacteria in the nasal microbiome caused alterations in the olfactory functions.
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