Here's how COVID-19 treatments are evolving.
When Dr. Carl June first heard about symptoms in seriously ill COVID-19 patients, his thoughts jumped to Emily Whitehead. Seven-year-old Emily had endured the same kind of immune over-reaction when June treated her in 2012 with an experimental therapy against her leukemia.In a last-ditch effort to save Emily's life, he had given her a drug, tocilizumab, that kept his own daughter's rheumatoid arthritis under control. To everyone's surprise, the drug worked.
Even after a vaccine is developed, treatments that save lives and prevent hospitalization will be crucial. Vaccines might not work for everyone and doses may initially be limited.The vast majority of people diagnosed with COVID-19 – more than 80% – will recover without the need for hospitalization or significant treatment.
Potential therapies being tested, experts said, fall into four major categories that are best used at different times:that slow or block the virus’ expansion in the body will be most effective early in infection, before the virus is fully established;that provide immune weapons to attack the virus once it’s established could help control infections and avoid the need for hospitalization;, most that tamp down an over-reacting immune system, will be particularly useful later in the course of...
At Penn, he and his colleagues have seen three types of patients: a large group whose immune system is over-reacting, a small group whose immune system is under-reacting, and others where the immune system is more balanced in the response.
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