The potential of mRNA vaccines goes beyond the coronavirus.
of the first molecules of life. While identified six decades ago as the carrier of the blueprint for proteins in living cells, its pharmaceutical potential was long underestimated. mRNA appeared unpromising—too unstable, too weak in potency, and too inflammatory.against Covid-19 in 2020 was an unprecedented achievement in the history of medicine. That success was built on iterative progress over decades, driven by the independent contributions of scientists around the world.
We now want to use this technology to tackle two of the world’s oldest and deadliest pathogens: malaria and tuberculosis. Worldwide, there are around 10 million new cases of tuberculosis every year. For malaria, the medical need is even higher: about 230 million malaria cases have been reported in the WHO Africa region in 2020, with most deaths occurring among children under 5.
The ongoing revolution in computational protein structure prediction allows for the modeling of three-dimensional structures of proteins. This is helping us decipher regions in these proteins that are optimal targets for vaccine development.
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