The effectiveness of mRNA vaccines during Omicron BA.4/5 predominance Coronavirus Disease COVID Omicron JAMANetworkOpen
By Pooja Toshniwal PahariaMar 21 2023Reviewed by Benedette Cuffari, M.Sc. The coronavirus disease 2019 pandemic has caused unprecedented morbidity and mortality across the globe, the mitigation of which is challenged by the continual emergence of increasingly transmissible and immune-evasive Omicron subvariants such as BA.4/5.
VE was assessed among adults against severe acute respiratory syndrome coronavirus 2 Omicron BA.4/5 sub-variant of concern infections. The relative COVID-19 severity among hospitalized patients with Omicron VOC BA.1 sub-VOC, BA.2 sub-VOC, BA.2.12.1 sub-VOC, or BA.4/5 sub-VOC infections was also assessed.
The participants were registered with nine VISION network healthcare systems across 10 states. Participant data were obtained from urgent care and emergency department encounters and hospital admissions of one or more days duration between December 16, 2021, and August 20, 2022. Individuals were excluded if they received booster vaccine doses prior to the recommended period for immunocompetent adults or received vaccines with a shorter time interval than recommended. In addition, individuals who received single COVID-19 mRNA vaccination, non-mRNA vaccinations, or were immunocompromised, were excluded.
VE estimates against hospital admission were 25% for two-dose vaccines more than 150 days post-vaccine administration, 68% for seven days to 119 days after receipt of the first booster vaccine dose, and 36% for over 120 days following receipt of the first booster dose.
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