COVID-19 patients with high blood sugar had low levels of a hormone made by fat.
, including many, like Sullivan, who were not previously diabetic, cardiologist James Lo and colleagues reported November 2 in. About 91 percent of the intubated COVID-19 patients had high blood sugar, as did almost 73 percent of people who died of the disease, the researchers reported.
Such sky-high levels of blood sugar were associated with a 15 times higher risk of intubation and 3.6 times higher risk of death compared with people with the disease who had normal blood sugar levels, Lo and colleagues found.Notes Pajvani, “we don’t know if the high blood sugar is causal of the bad outcome or reflective of the bad outcome.” Still, he and other doctors aren’t totally surprised by the connection between COVID-19 and high blood sugar, or hyperglycemia.
“The outlook was still bad, just not as bad in the group with ARDS and COVID, which is surprising,” says Ralph DeFronzo, an endocrinologist and chief of the diabetes division at the University of Texas Health Science Center at San Antonio, who was not involved with Lo’s study.Exactly what sends blood sugar soaring and causes diabetes in COVID-19 patients has been a mystery.
. Levels of several other hormones produced by fat cells were also out of whack, the researchers found. Experiments by other researchers have also indicated that SARS-CoV-2, the virus that causes COVID-19, can replicate in human fat, also known as adipose tissue, says Jose Aleman, an endocrinologist at the New York University Grossman School of Medicine. That’s yet another clue that fat is involved in severe disease.of 10 of 18 men who died of COVID-19, researchers in Germany report January 4 in. All 10 of the men with coronavirus in their fat were overweight or obese.
But the conclusion is not a slam dunk, Pajvani says. “This is an example of very good research done in very difficult settings.” But because the study looked back a group of patients, but didn’t match their characteristics and limit other variables from the beginning, the work can’t definitively show the cause of COVID-related diabetes. “This gives us a great hint of the type of study to do,” he says.
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