Researchers introduce the 'Telomouse'. By making a subtle genetic alteration in standard lab mice, they've made their telomeres, which protect the chromosome ends, more closely resemble those in humans.
Reviewed by Megan Craig, M.Sc.Nov 6 2023 Researchers introduce the "Telomouse". By making a subtle genetic alteration in standard lab mice, they've made their telomeres, which protect the chromosome ends, more closely resemble those in humans. Telomeres are critical for maintaining genetic integrity and promoting healthy aging while reducing cancer risk.
Telomeres hold a pivotal responsibility in safeguarding our genetic material and ensuring the orderly division of our cells. Maintaining their structural integrity and optimal length holds the potential to diminish the risk of cancer and facilitate a healthier aging process. However, a significant hurdle has emerged: conventional laboratory mice possess telomeres approximately five times longer than those in humans.
This study illuminates the central role of RTEL1 as the arbiter of telomere length. A nuanced modification to this crucial protein has enabled scientists to fashion a mouse model that closely approximates the human telomere length.
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