Symptoms of monkeypox differ from previous outbreaks Monkeypox Disease Virology Virus bmj_latest
By Dr. Liji Thomas, MDAug 1 2022Reviewed by Benedette Cuffari, M.Sc. Even as the coronavirus disease 2019 pandemic persists, an outbreak of the monkeypox virus is reaching unprecedented case numbers in non-endemic countries. A new BMJ study describes the clinical characteristics of monkeypox infections during the current outbreak from a large number of cases in central London.
In the United Kingdom, the first monkeypox case during the current outbreak was reported when the U.K. High Consequence Infectious Diseases network was informed about a man who had just returned from West Africa in early May 2022. This was followed by a total of over 1,700 cases reported by the second week of July.
In the U.K., four people have been diagnosed with monkeypox infection linked to travel to endemic countries since 2018. These four people had transmitted the virus to three others. Colorized transmission electron micrograph of monkeypox virus particles cultivated and purified from cell culture. Image captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID
This is in contrast to the current U.K. Health Security Agency guidelines for probable monkeypox which describe typical systemic symptoms as required. This is in addition to a skin rash and epidemiological risk factors, such as a history of contact with an infected individual or travel to an endemic region.
Over a third of patients present with lesions in various stages of evolution, perhaps because of repeated inoculation of the virus by the patient. Some patients exhibited maculopapular rashes that did not ulcerate or become pustular.
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