Nature research paper: Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ
, flow cytometry was used to measure the percentage of GFP-positive cells at different concentrations of NO. For each point, the mean of three biological replicates, each with n = 10,000 flow cytometry events, is plotted. Error bars are the standard error of the mean ., Detection of NO by the NO biosensor as a marker of GI inflammation in vivo over time, n = 10 animals per group. Data are represented as mean ± SEM, **p = 0.0012 , ***p = 0.0005 , ***p = 0.0002 , ****p < 0.
Extended Data Fig. 5 Design and manufacture of a bacteria-electronic pill casing compatible with ingestion., Size comparison of ingestible electronics and solid dosage forms with established safety rates. The safety of ingestible devices depends, in part, on ensuring that these devices will not damage, obstruct, or be retained in the GI tract.
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Correlated insulator collapse due to quantum avalanche via in-gap ladder states - Nature CommunicationsThe microscopic mechanism of the electric-field-driven insulator-metal transition in strongly correlated systems has been debated. Here the authors present a general theory based on a quantum avalanche mediated by the formation of in-gap ladder states from multiple-phonon emission.
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Targeted glioma therapy makes strides - Nature BiotechnologyIn Brief: Servier's successful phase 3 trial of vorasidenib in patients with a slow but usually fatal form of brain cancer, the first clinical breakthrough in the field for two decades, is likely to become a new standard of care
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Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer - Nature ChemistryThree-protein conjugates, which have so far been produced using protein-engineering strategies, can now be generated using a chemical approach that enables the addition of small-molecule functionality. Checkpoint inhibitory T cell engagers (CiTEs) were assembled and shown to have enhanced in vitro potency compared to a traditional T cell engager.
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Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles - Nature CommunicationsActive targeting and cytosolic delivery of therapeutic payloads are challenging in small extracellular vesicle-based drug delivery systems. Here, the authors engineer fusogen and targeting moiety co-functionalized cell-derived nanovesicles, which can selectively bind to target cells and efficiently fulfill cytosolic delivery through membrane fusion.
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'The World Without Us': The abandoned sites overrun by nature | CNNFrench photographer Romain Veillon has spent years photographing abandoned places around the world that have been overtaken by nature, with eerily beautiful results.
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