Study suggests blood group A may directly influence SARS-CoV-2 infectious risk BloodJournal BrighamWomens harvardmed ragoninstitute EmoryMedicine blood bloodgroup SARSCoV2 COVID19 coronavirus covid
By Pooja Toshniwal PahariaJun 29 2023Reviewed by Danielle Ellis, B.Sc. In a brief report recently published in Blood, researchers evaluated the association between blood group A and severe acute respiratory syndrome coronavirus 2 infections.
About the report In the present report, researchers describe increased coronavirus disease 2019 susceptibility among individuals with the A blood group. In addition, they examined Gal-4C, which failed to engage blood group antigens, as a control. To directly test whether key residues mutated in SARS-CoV-2 variants would be predicted to enhance A blood group binding, particularly in the SARS-CoV-2 Omicron variant of concern , the researchers compared the glycan binding of the SARS-CoV-2 Delta and Omicron VOCs to ABO antigens.
Further examination of every RBD variation revealed major modifications in glycan attachment interactions that seemed to be specific to each SARS-CoV-2 VOC. Despite modest changes in glycan attachment specificity across VOCs and various other cold CoV strain receptor-binding domains, the glycan interaction specificity of the RBDs studied remained remarkably similar compared to galectins, indicative of persistent conservation in the glycan attachment specificity.
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