A new study by University of Iowa researchers finds that rare lung cells known as pulmonary ionocytes facilitate the absorption of water and salt from the airway surface.
Reviewed by Danielle Ellis, B.Sc.Oct 24 2023 This function is exactly the opposite of what was expected of these cells and may have implications for cystic fibrosis lung disease.
Despite the implication that CFTR-rich ionocytes might play an important role in CF, the function of these cells has remained unclear. "The key feature that allows ionocytes to absorb chloride is the ionocyte-specific barttin chloride channel on the opposite membrane of the cell from the CFTR channel," says Ian Thornell, PhD, UI research assistant professor of internal medicine and senior author of the new study published in the Oct.16 issue of The Journal of Clinical Investigation.
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