Study uncovers proteomic signatures in blood plasma and cervicovaginal fluid that could lead to non-invasive detection methods for endometrial cancer, demonstrating significant potential for early diagnosis and improved patient outcomes.
By Tarun Sai LomteMar 24 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in eBioMedicine, researchers evaluated proteomic signatures in blood plasma and cervicovaginal fluid to detect endometrial cancer.
Over 90% of females with endometrial cancer present with postmenopausal bleeding, thus triggering urgent investigations through sequential transvaginal ultrasound, hysteroscopy, and endometrial biopsy, all of which could be anxiety-provoking and painful procedures. Therefore, developing simple, cost-effective, and non-invasive tests for early cancer diagnosis is crucial for both patients and clinicians.
Cervicovaginal fluid and blood were collected, and mass spectrometry was performed. Digitized proteomic maps were derived using sequential window acquisition of all theoretical mass spectra. Study findings Overall, 118 postmenopausal females with symptoms were included in the study, 53 of whom had confirmed endometrial cancer and 65 with no evidence of cancer. About 86% of the study cohort were White. Individuals with endometrial cancer were likely to be older and have a higher body mass index than controls.
The model with the top five discriminatory proteins had the lowest AIC value and was selected as a parsimonious model. This model predicted endometrial cancer with AUC, sensitivity, and specificity of 0.95, 91%, and 86%, respectively.
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