The most frequently reported adverse events in children on a JAK inhibitor were blood and lymphatic system disorders, in a review of FDA and Canadian adverse event reports.
Reports of blood and lymphatic disorders were higher in pediatric patients treated with Janus kinase inhibitors than in adults in a review of US and Canadian adverse event data, which also found thatResearchers analyzed 399,649 AEs in 133,216 adult patients and 2883 AEs in 955 pediatric patients from November 2011 to February 2023 using the US Food and Drug Administration; viral, fungal, and bacterial infections, such as pneumonia and sepsis ; constitutional symptoms and administrative...
In adults, the most common AEs were viral, fungal, and bacterial infections ; constitutional symptoms and administrative concerns ; musculoskeletal and connective tissue disorders ; and gastrointestinal and nervous system disorders., and psoriasis were the most common skin and subcutaneous tissue AEs reported in children. Skin and subcutaneous AEs were more common with upadacitinib , abrocitinib , and tofacitinib in children.
Serious AEs included in the boxed warning for JAK inhibitors — serious infection, mortality, malignancy, cardiovascular events, and thrombosis — were similar for baricitinib in children and adults . For other JAK inhibitors, absolute numbers of these AEs in children were small and rates were lower in children than in adults.Pharmacovigilance registries did not fully capture the complete range of AEs because of potential reporting bias or recall bias.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
ENT Specialty Head And Neck Surgery ENT Speciality Children Child Childhood Pediatrics Kids Pain Management Blood Canada Canadian Skin And Soft Tissue Infection Acne Acne Vulgaris Acneiform Eruptions Pediatric Dermatology Dermatitis Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology
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