Study on bacterial infection in older individuals Bacteria E coli Genetic Laboratory PublicHealth Research Streptococcus Pneumoniae UKBiobank SciReports UKHSA UniofOxford
Study: Laboratory diagnosed microbial infection in English UK Biobank participants in comparison to the general population. Image Credit: Kateryna Kon / Shutterstock
Serological studies have indicated that aging is associated with a gradual decrease in adaptive immunity, i.e., T-cell responses and antibody levels, which leads to an increase in pneumococcal pneumonia and herpes zoster infections. UKB is a prospective cohort that contains information on around 500,000 men and women aged between 40 and 69 between 2006 and 2010. Initially, this cohort was designed to evaluate the environmental and genetic determinants that lead to common life-threatening diseases.
The numbers of UK Biobank participants identified in each local authority in which recruitment occurred , and the percentage of the population in each local authority recruited . Maps were made with ARCGIS by UKHSA. Strengths of Record Linkage Monitoring microbiological isolations from more than 450,000 individuals present many research opportunities. Firstly, since UKB contains genomic data on the host, the genetic factor that enhances the risk of microbial infection in the older group can be investigated.
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