Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19 medrxivpreprint UniofOxford EdinburghUni OfficialUoM unisouthampton COVID19 coronavirus covid
By Dr. Chinta SidharthanSep 28 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers evaluated the efficacy of the anti-inflammatory drug dimethyl fumarate in treating coronavirus disease 2019 as part of an early phase, randomized, controlled assessment trial in the United Kingdom .
Dimethyl fumarate has displayed anti-inflammatory effects against severe acute respiratory syndrome coronavirus 2 in vitro and is thought to inhibit NLRP3 inflammasome activation. However, there have been no clinical trials until now to test the efficacy of DMF in reducing inflammation in COVID-19 patients.
Half the participants were randomly assigned to the usual standard of care, while the other randomized half was administered DMF along with standard care. Oral doses of 125 mg were administered every 12 hours for the first four days, and then the dosage was increased to 250 mg twice daily for the next eight days or until discharge.
Although DMF has been effective in inhibiting inflammasomes in vitro and has been successful in halving relapse rates in multiple sclerosis and treating psoriasis, it had no noticeable in vivo effects on COVID-19 outcomes. The authors believe that while DMF is known to inhibit inflammasome activation pathways, the progression of COVID-19 symptoms might not be directly related to these pathways. The other immunomodulators used in standard care could also have affected the efficacy of DMF.
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