New discovery could lead to the development of drugs that halt disease progression and stop memory loss. A scientific breakthrough in our understanding of Alzheimer’s disease has revealed changes to blood vessels in the brain, potentially presenting a path for developing new drugs to help fight t
A breakthrough in our understanding of Alzheimer’s disease could lead to new drugs that halt disease progression and stop memory loss.
The surface of the brain is covered with small arteries, called pial arteries, that control the brain’s supply of blood and oxygen. If these arteries become narrowed for too long, the brain can’t get enough nutrients. This is one of the causes of memory loss seen in people with the disease. To confirm that Aβ 1-40 stopped BK from working properly, they soaked healthy pial arteries in Aβ 1-40 and measured the signals sent by the BK protein after one hour. Aβ 1-40 weakened these signals, which caused the arteries to narrow.
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