Stopping a rare childhood cancer in its tracks CSHL naturecellbio
don't care," he says."The process by which the sarcoma forms turns this ETV6 molecule—this relatively innocuous, harmless protein that isn't doing very much—into something that's now controlling a life-death decision of the tumor cell."
When scientists blocked a protein called ETV6 in Ewing sarcoma cancer cells , they reverted back to normal connective tissue cells , which dramatically changed their shape, size, and behavior. Credit: Vakoc lab/Cold Spring Harbor Laboratory Postdoctoral researcher Yuan Gao works in Vakoc's lab. When Gao blocked ETV6 in Ewing sarcoma cells grown in the lab, she witnessed a dramatic transformation."The sarcoma cell reverts back into being a normal cell again," she says."The shape of the cell changes. The behavior of the cells changes. A lot of the cells will arrest their growth. It's really an explosive effect.
Vakoc and Gao hope other researchers will use what they've learned to begin exploring potential therapies for Ewingthat work by switching off ETV6. They say their biochemical analyses, which identify specific spots in the ETV6 protein that are key to its function in cancer cells, could help guide drug development.
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