Many patients with severe but stable heart disease who routinely undergo invasiv...
CHICAGO - Many patients with severe but stable heart disease who routinely undergo invasive procedures to clear and prop open clogged arteries would do as well by just taking medications and making lifestyle changes, U.S. researchers reported on Saturday.
The $100 million government-backed study, presented at the American Heart Association meeting in Philadelphia, is the largest yet to look at whether procedures to restore normal blood flow in patients with stable heart disease offers an added benefit over more conservative treatment with aspirin, cholesterol-lowering drugs and other measures.
NYU Langone cardiologist Dr. Judith Hochman, who chaired the study, estimated that some 500,000 new patients a year are diagnosed with stable coronary artery disease, in which heart arteries narrowed by fatty deposits cause periodic angina, or chest pain, typically after exercising or emotional distress.
The 7-year, 5,179-patient ISCHEMIA study did not show a significant benefit from that course of action. “I would hope this would change practice,” said Dr. William Boden of the VA New England Healthcare System, another study author. “We are wasting a lot of money.” The trial, sponsored by the National Heart, Lung and Blood Institute, involved patients with moderate to severe but stable ischemia - a condition in which clogged arteries are not able to supply the heart with enough oxygen-rich blood.
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