The force said the youngsters, whose ages have not been confirmed by police, remain in hospital and five people have been arrested.
Thames Valley Police said officers tried to stop a BMW which was driving "erratically" at high speed on the city's eastern bypass at 11.10pm on Tuesday. The car failed to stop and five minutes later it collided with a black VW Touran driving along The Slade.
Five young men, who are all from the city, have all been arrested on suspicion of causing serious injury by dangerous driving. The fourth suspect, also 19, was also arrested on suspicion of driving a vehicle with a proportion of a specified controlled drug over the specified limit and has been bailed.
Detective Inspector Justin Thomas, from the force's Serious Collision Investigation Unit, said: "We would like to appeal to anybody who may have witnessed this incident or was in the area at the time of the collision.Get daily news updates with our WhatsApp news service Daily Record has launched a WhatsApp news service to keep you up to date with the latest Scottish news.If the link doesn’t work, click here for an alternative way to sign up and more information about the service.
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