Nature research paper: Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
, CV1 and Treg, or CV2 and CD4+. Dashed line represents the identity line. Only eGenes with significant interaction and labelled traits have Fisher p = 0.5., secondary effects in ATAC-seq peaks from Calderon, et al. 2019. Peaks were binarized as present or not in each sample at a threshold of > 5 CPM.
In all plots, the height of the grey bar corresponds to the average enrichment calculated across all loci containing a variant with PIP = 0.001 are labelled with their one-sided p-value and with corresponding asterisks. Each pair of interacting/non-interacting bars is labelled with a one-sided permutation p value for the difference . The grey dotted line indicates enrichment statistic = 1.
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