More research is needed, but the potential is immense.
, scientists have discovered that molecules called microRNAs regulate the release of GnRH.
In a pilot experiment involving mice with three copies of chromosome 21, a team led by neuroscientist Vincent Prevot of the University of Lille in France found that increasing the levels of GnRH using microRNAs was able to reverse the effects Down syndrome had on the animals' olfactory senses and other cognitive deficits.
Of course, an animal study doesn't prove anything for humans. But a followup experiment involving seven men with Down syndrome who received GnRH from a pump under their skin showed hopeful results as well.
"The human experiment is very preliminary and lacks controls," geneticist Stylianos Antonarakis of the University of Geneva, who was not involved, told the magazine.Prevot is now planning a follow-up clinical trial later this year that will involve 70 male and female patients across several institutions.
"If GnRH therapy improves cognition in this large cohort of Down syndrome patients, many possibilities are open," he toldstudy studying the effects of a similar molecule to GnRH for treating Alzheimer's is already underway.
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