Researchers have identified a molecule with enhanced antiproliferative activity in cancer cells Vitamin D3 performs critical biological tasks such as maintaining bone mineral density, which reduces the risk of bone fracture. However, vitamin D3 is thought to have anti-cancer effect, since low level
The biomolecular mechanism behind the molecule is the suppression of an enzyme that is overproduced in various forms of cancer.Vitamin D3 performs critical biological tasks such as maintaining bone mineral density, which reduces the risk of bone fracture. However, vitamin D3 is thought to have anti-cancer effect, since low levels of vitamin D3 and the concomitant overproduction of an enzyme called CYP24 have been linked to a bad prognosis for cancer patients.
The researchers tested a vast number of DNA aptamers, which are single-stranded DNA fragments with specialized three-dimensional structures that can bind to certain target molecules and have a functional effect when bound. They sought for DNA aptamers that bind to CYP24 but not to the similar enzyme CYP271B, which is responsible for vitamin D3 synthesis.
Internalization of aptamer into A549 cells is indispensable for CYP24 inhibition and enhancing 1, 25-D3 mediated cell-growth inhibition. Internalization of Aptamer into A549 cells. A549 lung cancer cells were treated with 500 nM aptamer Apt-7 and had their membranes stained green Conjugates). Confocal microscopy revealed the intracellular signal, derived from internalized aptamer . Apt-7 inhibits the CYP24-mediated catabolism of 1,25-D3 in A549 cells.
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