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Our immune system is talented at telling the difference between the chemistry of our own body and that of an invading pathogen. When it malfunctions, our body can become
"Along with previously defined interactions with nucleosomes, our results provide a complete structural model of the nuclear regulation of cGAS,"that as cells divide to grow, the nuclear envelope dissolves, giving cGAS easy access to the DNA bundled within. There, it binds to DNA packaging units called nucleosomes and is covered by a protein called BAF, waiting for when it might be needed.
"These results demonstrate that nuclear cGAS levels affect the cellular IFN tone and reveal a role for CRL5–SPSB3 in cell-intrinsic immunity,"and inflammatory bowel disease, happen when immune system controls don't function as they should. The new research highlights one of those controls as worth studying further.
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