María Eugenia Gomez-Casati and her team from the Institute of Pharmacology, School of Medicine, University of Buenos Aires-CONICET, alongside Mauricio Martin from the Institute of Medical Research Mercedes, and Martín Ferreyra from INIMEC-CONICET-UNC, National University of Córdoba in Argentina, hav
Researchers found that age-related hearing loss is linked to decreased cholesterol in the inner ear. Their experiments revealed that phytosterol supplements can replace lost cholesterol and prevent sensory malfunction in mice.
in Argentina, have discovered a connection between age-related hearing loss and reduced cholesterol levels in the inner ear., show that phytosterol supplements were able to act in place of the lost cholesterol and prevent sensory dysfunction in mice. First, the researchers measured the amount of CYP46A1 in inner ear OHCs because this enzyme helps break down and recycle cholesterol. As expected, they found more CYP46A1 in the inner ears of older mice than in younger mice, and consequently less cholesterol. Next, they showed cause and effect by inducing hearing loss in young mice, as indicated by abnormal inner ear-cell output, by over-activating CYP46A1 with a drug.
As phytosterols can be found in many over-the-counter supplements, they could be a convenient way to combat age-related hearing loss. However, directly testing their effects on hearing loss in older mouse models as well as in humans will be necessary before more definite conclusions can be made.
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