Scientists discover superbug's rapid path to antibiotic resistance

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Scientists discover superbug's rapid path to antibiotic resistance
Today's HealthcareInfectious DiseasesHIV And AIDS
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Scientists have discovered how the hospital superbug C.diff rapidly evolves resistance to the frontline drug used for treatment in the UK.

Clostridioides difficile , a type of bacteria which often affects people who have taken antibiotics, is responsible for approximately 2,000 deaths annually in the UK.

Despite vancomycin's critical role within UK healthcare, routine monitoring for resistance in clinical settings is lacking, so resistance may be emerging under the radar in hospitals. If widespread resistance were to arise it would remove this critical treatment option from UK healthcare. "Our ongoing work aims to understand the extent and mechanisms of resistance development, simulate these conditions within the complex human gut ecosystem, and collaborate with UK epidemiologists to identify potential resistance signatures in hospitals.

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