Researchers believe there may be a way to target ‘sleeping’ breast cancer cells and prevent relapse.
Scientists have discovered how breast cancer cells can evade treatment by “hibernating” and then “wake up” years later – causing a relapse that is more difficult to treat.
Luca Magnani, professor of epigenetic plasticity at The Institute of Cancer Research, London, said: “After surgery to remove primary oestrogen receptor positive breast cancer, patients are given five to 10 years of hormone therapy which aims to kill any remaining cancer cells. “Our research identified a key mechanism used by cancer cells to evade therapy by remaining in a dormant state, hibernating before they ‘wake up’ years later and begin to rapidly divide again.
Treatment often involves a combination of different therapies and surgery, usually tailored to the patient’s needs. Dr Tayyaba Jiwani, science engagement manager at Cancer Research UK – which funded the research, said: “Breast cancer survival has doubled in the UK over the last 50 years thanks to better detection and screening, but there are still more than 11,000 deaths from this type of cancer every year.
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Scientists discover how breast cancer cells become dormant and evade treatmentResearchers believe there may be a way to target ‘sleeping’ breast cancer cells and prevent relapse.
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