Researchers at Stockholm University have unveiled the hidden intricacies of how sperm go from passive bystanders to dynamic swimmers.
Reviewed by Megan Craig, M.Sc.Oct 25 2023 This transformation is a pivotal step in the journey to fertilization, and it hinges on the activation of a unique ion transporter.
It's exclusively found in sperm cells, and it is usually not active. However, when the chemo-attractants interact with the sperm's surface, everything changes. Researchers, led by David Drew, have unveiled the secrets behind SLC9C1's inner workings and provides the first example of voltage-sensing domain activation of a transporter and its connection via an unusually long voltage-sensing helix.
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