The development of sex-specific characteristics is frequently seen in mammals. These characteristics stem from the activation of corresponding genetic programs that until now have been largely undescribed by the scientific community.
Reviewed by Megan Craig, M.Sc.Nov 2 2023 An international research team from the Center for Molecular Biology of Heidelberg University and The Francis Crick Institute in London has, for the first time, decoded the programs that control the sex-specific development of major organs in selected mammals – humans, mice, rats, rabbits, and opossums. By comparing these programs, the researchers were also able to trace the evolution of sex-specific organ characteristics.
The development of mammalian organs before and after birth is controlled by the finely tuned and complex interaction of many different genes – also known as gene expression programs. "Overall, this development-related gene expression is fairly well understood, among other things through the work in our lab.
To also understand the evolution of these gene regulatory programs, the researchers compared their results for the various mammals in detail.
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