SARS-CoV-2 reinfection uncommon among individuals with evidence of previous infection during the pre-vaccine era PLOSONE theNCI SARSCoV2 reinfection infection covid coronavirus COVID19 vaccine
By Bhavana KunkalikarMar 27 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the PLOS ONE journal, researchers in the United States assessed the risk associated with severe acute respiratory syndrome coronavirus 2 reinfection.
About the study In the present study, researchers explored the duration of SARS-CoV-2 infection's protective effect against reinfection. The study population comprised 144,678,382 persons gathered from US real word data sources vetted by HealthVerity, and medical service data obtained between February 2, 2020, and April 30, 2021.
A cohort of SARS-CoV-2-positive patients was identified for the secondary outcome. Individuals were recruited according to their first positive SARS-CoV-2 NAAT or antibody test result between February 29, 2020, and December 9, 2020. During the follow-up period, 737,742 instances of infection were noted in the unmatched population, and 8,869 cases were noted in the index-positive cohort. During follow-up, the crude reinfection rate was significantly lower in the index-positive cohort than in the index-negative cohort. During the 375 days of follow-up after the index date, the cumulative incidence of reinfection was almost 0.85% among index-positive persons and 6.2% among index-negative persons.
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