Ribosomal gatekeepers: Study sheds light on molecular control centers of eukaryote protein factories unikonstanz sciencemagazine
—the membrane network inside the cell—by specifically bringing together protein and transport molecule ," Deuerling said, summarizing the previous study results.
In their new study, the researchers now show that the gatekeeper's sorting function is more extensive and even more significant than previously known, and that NAC also ensures the correct methionine excision from nascent proteins.is part of a transport signal."Methionine excision in these proteins would destroy the signal and thus prevent its transport into the cell's membrane network, which would inevitably lead to cell death," Gamerdinger explains.
This changes as soon as a protein with a transport signal leaves the ribosomal tunnel. Interactions between the protein's signal sequence and NAC then cause the gatekeeper to change its own position at the ribosomal tunnel. As a result, METAP1 loses its binding to NAC and thus its ability to cleave off methionine. With the changed position of the gatekeeper, a new binding interface becomes accessible for the transport molecule SRP.
excision. Those, in contrast, that are transported to the endoplasmic reticulum, remain unaffected by METAP1," Gamerdinger explains.The researchers hypothesize that NAC may have other similar mediating functions at the ribosomal tunnel, thus assuming the role of a general molecular control center.
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