A research team has successfully developed a biomimetic chip that combines organoid and organ-on-a-chip technologies to simulate the complex defense mechanisms of the human gastric mucosa.
A groundbreaking development in biomedical engineering has led to the creation of a human stomach micro-physiological system , representing a significant leap forward in understanding and treating various gastrointestinal diseases, including stomach cancer.
The newly developed biochip incorporates fluid flow within its microfluidic channels to simulate mechanical stimuli and facilitate cell-to-cell interactions. Mesenchymal substrate cells exposed to fluid flow activate gastric stem cell proliferation while promoting cellular differentiation balance. This process ultimately mimics key features necessary for developing functional gastric mucosal barriers at a biologically relevant level.
"This study presents our model's potential for observing dynamic interactions between epithelial cells and immune cells in chips infected with Helicobacter pylori, contributing to a comprehensive understanding of gastric mucosal barrier stability," explained Professor Park.
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