Integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types.
By Tarun Sai LomteOct 24 2023Reviewed by Lily Ramsey, LLM In a recent study published in Cell, researchers integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types to trace the cellular origin of nearly 6,000 proteins in the aqueous humor .
In addition, it cannot be inferred whether a given messenger RNA is translated; thus, studying proteome-wide relevance to human disease is challenging. The team confirmed gene expression of 5,923 proteins within RNA-seq data. There were 5,887 locally expressed genes in the eye. Unsupervised cluster analysis of 5,923 genes revealed cell-type-dependent clustering.
Further, the team also tested uveitis patients and observed a significant increase in markers from several immune cells . Besides, they observed molecular damage from uveitis in other retinal cell types, such as amacrine cells, bipolar cells, and cone photoreceptors. Further, the authors analyzed AH from patients with Parkinson’s disease . Among 48 PD-relevant proteins, 18 were present in the AH, including nine significantly increased PD.
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