Scientists have identified the gene Dyrk1a and at least three other genes as responsible for facial and skull structural changes in a mouse model of Down Syndrome. The research helps advance understanding of the genetics behind Down Syndrome and may contribute to developing targeted treatments for a
have shed light on the genetics behind changes in the structure and shape of the face and head in a mouse model of Down Syndrome., the researchers found that having a third copy of the geneand at least three other genes were responsible for these changes taking place in development – called craniofacial dysmorphology – which involve shortened back-to-front length and widened diameter of the head.
Using genetic engineering, teams led by Victor Tybulewicz of the Francis Crick Institute and Elizabeth Fisher of University College London created mouse strains with duplications of three regions on mouse chromosome 16, which mimics having a third chromosome 21. The mice show lots of traits associated with Down Syndrome, including changes in the shape of the face and skull.to aspects of Down Syndrome, so the researchers wanted to test how it impacted craniofacial dysmorphology.
Victor Tybulewicz, Group Leader of the Down Syndrome Laboratory at the Crick, who worked with first author Yushi Redhead, said: “There’s currently limited treatments for the aspects of Down Syndrome which have a negative impact on people’s health, like congenital heart conditions and cognitive impairment, so it’s essential we work out which genes are important.
Researchers at King’s College London used shape-measuring tools to map the changing skull shape of the mice. These showed changes in skull shape that were remarkably similar to those seen in people with Down Syndrome.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Mattel introduces first Barbie doll representing a person with Down syndromeThe new doll is part of Mattel Barbie Fashionistas line, which aims to offer kids more diverse representations of beauty and fight the stigma around physical disabilities.
続きを読む »
Mattel introduces first Barbie doll representing a person with Down syndromeThe new doll is part of Mattel Barbie Fashionistas line, which aims to offer kids more diverse representations of beauty and fight the stigma around physical disabilities.
続きを読む »
Mattel introduces first Barbie doll representing a person with Down syndromeThe new doll is part of Mattel Barbie Fashionistas line, which aims to offer kids more diverse representations of beauty and fight the stigma around physical disabilities.
続きを読む »
Mattel introduces first Barbie doll representing a person with Down syndrome | CNN BusinessMattel on Tuesday introduced its first-ever version of the Barbie doll representing a person with Down syndrome.
続きを読む »
Barbie Introduces New Doll Representing Person With Down SyndromeMattel unveils a new Barbie doll Tuesday representing a person with Down syndrome 'to better reflect the world around us and further our commitment to celebrating inclusion through play.'
続きを読む »
Barbie releases new doll with Down syndromeAbout 6,000 children are born with Down syndrome every year in the U.S. Now, they will have a Barbie doll representing them.
続きを読む »