Researchers are studying the signaling pathway that leads the parasite responsible for Chagas disease to transform and reproduce. They follow that pathway from the beginning when an uninfected kissing bug acquires the parasite by biting an infected mammal host all the way to the time the parasite develops in the insect's gut to be spread to people or animals through the bug's poop.
Almost everything about insects called kissing bugs is revolting, from the insidious way they bite people's faces at night to drink their blood while they sleep to the way they spread disease through their poop.
UC researchers are studying the signaling pathway that leads the parasite to transform and reproduce. They follow that pathway from the beginning when an uninfected kissing bug acquires the parasite by biting an infected mammal host all the way to the time the parasite develops in the insect's gut to be spread to people or animals through the bug's poop.
They also discovered two regions within the cell where an important"messenger molecule" called cyclic adenosine monophosphate, or cAMP, is responsible for the parasite's life cycle transformations in response to environmental stress. Kissing bugs are often found in older or poorly constructed homes. Sometimes they live in thatched roofs.
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