A study spearheaded by Oregon State University has shown why certain polyunsaturated fatty acids work to combat a dangerous liver condition, opening a new avenue of drug research for a disease that currently has no FDA-approved medications.
Scientists led by Oregon State's Natalia Shulzhenko, Andrey Morgun and Donald Jump used a technique known as multi-omic network analysis to identify the mechanism through which dietary omega 3 supplements alleviated nonalcoholic steatohepatitis, usually abbreviated to NASH.
NASH is associated with a disorder known as metabolic syndrome. It develops when fat in the liver becomes toxic, killing liver cells, inflaming the organ and promoting fibrosis. The disease can lead to permanent scarring , liver failure and possibly death. "Via large meta-analysis, we found betacellulin is consistently up-regulated in livers of cancer patients – there's more of it than there should be," Morgun said. "And omega 3 PUFA lower, or down-regulate, betacellulin in both mice and humans with NASH. Targeting betacellulin expression is one of the mechanisms for omega 3 PUFA reduction of western-diet-induced NASH."
In addition to dietary supplements, omega 3 PUFA, such as docosahexaenoic acid, are found in cold-water fatty fish such as salmon and mackerel and in some nuts, seeds and plant oils.
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