A group of Kyoto University researchers have developed a method to study early facial development by producing neural crest cell-rich aggregates from human pluripotent stem cells. These aggregates differentiate into cell populations with a branchial arch-like gene expression pattern and spontaneously form patterns of the facial primordium.
Mother Nature is an artist, but her craft of creating animal faces requires more than a paintbrush and palette. Such highly complex shapes originate from their respective transient neural crest cells . These embryonic pluripotent cells within the facial primordium -;the early development form-;may be necessary for forming proper facial structures. However, analyzing the molecular mechanisms in such early stages of development poses many technical challenges.
Now, a group of Kyoto University researchers have produced neural crest cell-rich aggregates from human pluripotent stem cells and developed a method to differentiate them in cell populations with a branchial arch-like gene expression pattern. After the cell populations differentiate into precursors of maxillary and mandibular cells in response to external signaling factors, these populations spontaneously form patterns of the facial primordium." Yusuke Seto of KyotoU's Institute for Medical and Biological Research This cartilage-like structure, reminiscent of Meckel's cartilage, is formed locally within the aggregates. "We aim to establish a model for studying early facial development by using the properties of human pluripotent stem cells to generate in vitro tissue resembling the bronchial arch of the primordial face," adds Ryoma Ogihara, also of the Institut
Kyoto University Researchers Method Study Early Facial Development Neural Crest Cells Pluripotent Stem Cells Aggregates Gene Expression Pattern Facial Primordium
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