A new study finds that consanguinity—unions between close relatives—may increase the risk of common diseases such as type 2 diabetes and post-traumatic stress disorder (PTSD).
Consanguinity is the social and cultural practice of marriage between two blood-related individuals who share a recent common ancestor, for example a grandparent or great-grandparent. This practice is observed across the world with varying prevalence. Over 10% of the global population consists of individuals who are the offspring of second cousins or closer. In the UK, consanguinity is more common among some British South Asian communities.
The teams analyzed genomic data to describe different patterns of consanguinity in distinct populations, including 23,978 British individuals of Pakistani and Bangladeshi descent from the Genes & Health cohort, and 397,184 individuals of European or South Asian descent from the UK Biobank cohort. Within this restricted"highly consanguineous" group, the precise level of autozygosity is randomly determined, between 4–15%, and the researchers showed that it is not correlated with sociocultural and environmental factors, such as religiosity, education or diet, which might themselves influence health traits. This novel method helped ensure any observed links between autozygosity and diseases were biological in cause, rather than due to confounding.
Daniel Malawsky, first author of the study and Ph.D. student at the Wellcome Sanger Institute, said,"While consanguinity has a smaller role in common diseases compared to other factors, it is still essential to understand its specific influence on health in these communities. Our new method exploring the natural variation in expected autozygosity among offspring of first cousins was a key breakthrough in helping us to test its impact.
"The research team actively engaged community members, taking into account our traditions, cultures, and religious practices. By empowering people with the knowledge to make informed health decisions, we can help tackle the health disparities in our communities, especially in diseases like type 2 diabetes."
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Research team uses immersive VR to shed light on tactile gating and 'phantom touch illusion'If you've ever tried to tickle yourself, you may not have succeeded. This is due to your nervous system suppressing the expected sensation of your own actions, a mechanism known as tactile gating. Until now, this mechanism has been understood as a complex sensory process occurring in response to the activation of tactile receptors.
続きを読む »
Shropshire companies urged to add their views to skills researchShropshire businesses are being urged to help shape the future of skills training across the region by taking part in a research project.
続きを読む »
Slowing human ageing is now the subject of serious researchAnd some of it is making progress, writes Geoffrey Carr
続きを読む »
Boston seeks partners in research study on city's ties to slaveryThe City of Boston announced on Monday that it’s looking for partners to put together research on the city’s ties and role in slavery, as its Reparations Task Force moves forward with understanding and addressing the legacy of the slave trade. Mayor Michelle Wu and the Boston Reparations Task Force announced Monday the release of a request for proposals for…
続きを読む »
Antibiotics can help certain bacteria survive for longer, research suggestsUntil now it had been thought that antibiotics kill bacteria or stop them growing.
続きを読む »
Antibiotics can help certain bacteria survive for longer, research suggestsUntil now it had been thought that antibiotics kill bacteria or stop them growing.
続きを読む »