Synthetic Molecules that Adhere Cells Could Galvanize Regenerative Medicine Scientists at the University of California, San Francisco (UCSF) have engineered molecules that act like “cellular glue,” allowing them to direct in precise fashion how cells bond with each other. The discovery represents a
Molecules that act like “cellular glue” have been developed by researchers, enabling them to control exactly how cells bond with each other. This represents a significant advancement towards the construction of tissues and organs, which has been a key objective in the field of regenerative medicine for a long time.
Wendell Lim, PhD, director of UCSF’s Cell Design Institute, holds a cellular model in his office at UCSF’s Mission Bay Campus. Credit: Elena ZhukovaBodily tissues and organs begin to form in utero and continue developing through childhood. By adulthood, many of the molecular instructions that guide these generative processes have disappeared, and some tissues, like nerves, cannot heal from injury or disease.
Much of what makes a given tissue distinct is how tightly its cells are bonded together. In a solid organ, like a lung or a liver, many of the cells will be bonded quite tightly. But in the immune system, weaker bonds enable the cells to flow through blood vessels or crawl between the tightly bound cells of skin or organ tissues to reach a pathogen or a wound.
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