Doctors have started reporting rare cases of patients whose symptoms return several days after completing Paxlovid's five-day regimen of pills.
for adults at high risk of severe COVID-19 based on a study in which 1,000 adults received the medication.Doctors have started reporting rare cases of patients whose symptoms return several days after completing Paxlovid's five-day regimen of pills. That's prompted questions about whether those patients are still contagious and should receive a second course of Paxlovid.
Could some people just be susceptible to a relapse? Both the FDA and Pfizer point out that 1% to 2% of people in Pfizer’s original study saw their virus levels rebound after 10 days. The rate was about the same among people taking the drug or dummy pills, “so it is unclear at this point that this is related to drug treatment,” theSome experts point to another possibility: The Paxlovid dose isn’t strong enough to fully suppress the virus.
That may come from a large, ongoing Pfizer study that includes high-risk vaccinated people. No results have been published; the study is expected to wrap up in the fall.
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