Cancerpatients often experience depression, but traditional treatments may not provide significant relief. To address this issue, a group of researchers has experimented with a unique approach to treating depression in cancer patients: psilocybin.
After 30 adult patients with cancer — all with a major depressive episode and 16 with incurable metastatic disease — took a one-time 25-mg dose of psilocybin under medical supervision, half had complete remission of their depressive symptoms and 30% showed sustained improvements at 8 weeks. The treatment was safe, with no treatment-related serious adverse events.
But he agreed that the research is still young. The next step would be a randomized trial that pits psilocybin against placebo or traditional therapies, such as selective serotonin reuptake inhibitors. Using the 60-point Montgomery–Asberg Depression Rating Scale, patients had a mean baseline score of 25.9 points, indicating moderate depression, and some patients scored in the severe range.
Agrawal acknowledged that psilocybin treatment is intense and often grueling for patients, especially at the 25-mg dose used in the study.the general outcome is a major shift in perspective. Patients are not as caught up in living their story; instead, they're able to see their story from the outside and how it fits into a larger context, Agrawal said.
"Her psilocybin experience allowed her to have this sort of insight. You talk to patients about death being a natural part of life," but it's just a thought, he said."For her, to feel it somewhere inside and not just cognitively, that is the thing that helped her," he added.
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