Proteomics reveals a distinct IFN-driven plasma cytokine response to COVID-19 in infants and young children ChildHealth Proteomics Coronavirus Disease COVID Immunity SARSCoV2 medrxivpreprint Stanford uni_tue CincyChildrens EmoryUniversity
By Dr. Priyom Bose, Ph.D.Feb 5 2023Reviewed by Benedette Cuffari, M.Sc. Although the severe acute respiratory syndrome coronavirus 2 , the causal agent of the coronavirus disease 2019 pandemic, predominantly infects adults, many children and infants can contract the mild or asymptomatic infection. Nevertheless, severe infection and mortality rates associated with COVID-19 are low among children.
Thus, the extent to which infants develop durable antibody responses, as well as T- and B-cell memory, to SARS-CoV-2 needs to be investigated. It is equally important to understand how COVID-19 impacts the maturing of infants' immune systems in the long term. Blood samples were also obtained from 48 adult COVID-19 patients and ten healthy adults, whose average age was around 59 years.
The experimental results of the current study also revealed that infants are vulnerable to new SARS-CoV-2 variants of concern. This finding was based on reduced serum neutralization titers in infants and young children infected with Omicron sublineages, such as BA.1, BA.2, BA.3, and BA.4/5, as well as the Delta variant.
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