According to a study conducted by the Swiss Tropical and Public Health Institute (Swiss TPH) and partners, results show that the promising antimalarial drug, rectal artesunate (RAS), is ineffective at saving the lives of young children who are suffering from severe malaria. The viewpoint about the s
The study, conducted in the DR Congo, Nigeria, and Uganda, which aimed to investigate the large-scale roll-out of the antimalarial drug RAS, has found that when used as an emergency treatment in real-world conditions, RAS was not effective in improving the survival rate of young children suffering from severe malaria.
The observational study, which included 6,200 severely ill children under the age of 5 years, found that in some instances, the children who received RAS were more likely to die than those who did not. “RAS was previously shown to have a beneficial effect if it is followed by adequate post-referral care at a hospital, which raised hopes in the malaria community,” added Hetzel.
Based on the results of this new study, the WHO issued an Information Note in October 2021 recommending that countries either delay scale-up until further guidance on the safe implementation of RAS is made available or urgently review the conditions under which it is currently being used. At present, the current WHO guidelines on RAS are under review by a team of WHO-appointed experts.
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