Pilot study demonstrates that electrophysiologically-guided DeepBrainStimulation of the nucleus accumbens improved self-control of food intake and weight loss in two individuals with BingeEatingDisorder and severe obesity. DBS Brain Biomarkers
The closed-loop intracranial stimulation system used here for rDBS was a brain RNS System currently approved by the US FDA for the treatment of adults with medically refractory focal-onset seizures. The system consists of two intracranial recording and stimulating electrodes connected to a neurostimulator implanted in the skull. The neurostimulator continuously monitors electrographic signals and detects abnormal electrophysiological activity to trigger brief bursts of electrical stimulation.
During the end of the recording phase of the study and after optimization of signal detection, both subjects underwent a day of monopolar survey testing of all the electrode contacts to screen for any acute stimulation effects. One week after this survey testing, each subject was randomized in a single-blind fashion to receive a week of active or sham rDBS unilaterally to assess initial tolerability and optimize stimulation parameters.
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