Depression linked to immune response in some people MolPsychiatry
. Systematic search of the PubMed and PsycINFO databases was carried out to identify all published studies of peripheral blood cellular immunophenotype in depression from database inception to 5April 2022. Search terms incorporated key indexing terms and wildcards to maximise return and included: AND . The full search strategy is presented . Our search was restricted to English language articles and human participants.
Included studies were: original articles; written in English; based on human subjects; cohort or case-control in design; compared immune phenotype between current depression cases and controls; defined depression using clinical diagnosis, diagnostic interview using the International Classification of Diseases or the Diagnostic and Statistical Manual of Mental Disorders criteria, or using a validated depression scale score cut-off; defined controls as individuals with no lifetime history of...
The methodological quality of each study was assessed using an adapted version of the Newcastle-Ottawa Scale for case-control studies []. One NOS scoring item was deemed irrelevant for the current investigation and so, the maximum possible NOS score here was eight. EMF and JTP performed quality assessment independently. Any differences were resolved by further discussion and consensus involving GMK.
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