Using a randomised three-way crossover design and stratification approaches, the TriMaster study demonstrated that patients with obesity and type 2 diabetes were more likely to have greater glycaemic control with pioglitazone than on sitagliptin IDF2022
All analyses were carried out in line with the TriMaster Statistical Analysis Plan, which was approved before data lock and drug allocations being provided. Investigation of participant preference, including additional exploratory analysis, is reported separatelyAll analysis was carried out using a validated version of Stata 16.1.
Weight: We assessed differences in weight by drug/stratum as in the primary analysis hypotheses using similar mixed effects models to those used in primary analysis but with weight as the outcome. Overall side effects: This analysis was descriptive, examining the proportions reporting experiencing each of the 16 side effects that the patients were asked about for each of the three drugs.
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