Nature research paper: Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis
The interleukin-17 family of cytokines and receptors play central roles in host defense against infection, and development of inflammatory diseases. The compositions and structures of functional IL-17 family ligand-receptor signaling assemblies remain unclear. Interleukin-17E is a key regulator of Th2 immune responses and driver of inflammatory diseases such as allergic asthma and requires both IL-17 receptor A and IL-17RB to elicit functional responses.
The IL-25–IL-17RB–IL-17RA ternary signaling assembly is a c2-symmetric complex in which the IL-25–IL-17RB homodimer is flanked by two “wing-like” IL-17RA co-receptors through a “tip-to-tip” geometry that is the key receptor-receptor interaction required for initiation of signal transduction. IL-25 interacts solely with IL-17RB to allosterically promote the formation of the IL-17RB–IL-17RA tip-to-tip interface.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
'Zombie Cells' Are Still Alive But Can't Function, And They Accumulate as We AgeDamage to the ends of your chromosomes can create 'zombie cells' that are still alive but can't function, according to our recently published study in Nature Structural and Molecular Biology.
続きを読む »
'Good Trouble': 17 House Democrats Arrested Protesting Roe Reversal at Supreme Court'We won't stop our organizing, agitating, and legislating for justice,' declared Rep. Cori Bush, who was among 17 members of Congress arrested outside the U.S. Supreme Court while protesting the recent reversal of Roe v. Wade.
続きを読む »
Opinion: Why is a euro only worth $1? The U.S. central bank made a better bet than Europe's.Europe wagered that inflation will just kind of fade away once a few “structural...
続きを読む »
Lawsuit Says Tesla Painted Over Structural Crack in Model 3An investigation commissioned by a regional court found safety defects that would cause two Teslas to fail safety inspections.
続きを読む »
Houdini, The Woolmark Company Debut ‘The New Naturals’ LineThe New Naturals collection is described as a “love affair between nature and technology.”
続きを読む »
See What's Under The Lid Of Tesla's 4680 Structural Battery PackMunro Live released today another update on the Made-in-Texas (MIT) Tesla Model Y's structural battery pack teardown.
続きを読む »