In the U.S., more than half a million people died from overdoses involving opioids between 1999 and 2020.
In an interesting twist, researchers are now looking to cannabidiol , a component of marijuana, as a possible alternative to the popular opioid antidote, naloxone, according to new research presented at theBetter yet, rather than replacing naloxone, CBD could work alongside it. That is, CBD was found to reduce the binding of fentanyl- a powerful synthetic opioid- thereby boosting the effects of naloxone.are drugs prescribed to relieve pain but are frequently sold illegally.
"Fentanyl-class compounds account for more than 80 percent of opioid overdose deaths, and these compounds aren't going anywhere — it's just too much of an economic temptation for dealers," said Alex Straiker, Ph.D., the project's co-principal investigator in a"Given that naloxone is the only drug available to reverse overdoses, I think it makes sense to look at alternatives.", naloxone reverses an overdose. However, fentanyl binds more quickly than naloxone does.
The current endeavor was motivated by earlier research that suggested CBD might interfere with opioid binding. Here, a team from Germany discovered that CBD accelerated the effects of naloxone, forcing the receptors to release opioids.Now, Gudorf and colleagues changed the structure of CBD to produce derivatives. They evaluated these new compounds using the only opioid employed in lab experiments- DAMGO.
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