Old antibiotic nitroxoline suggested as a treatment for MPOX Antibiotic Bacteria Drugs Monkeypox Virus Virology nitroxoline antimicrobial biorxivpreprint goetheuni HumboldtUni DZIF_
Study: Repurposing of the antibiotic nitroxoline for the treatment of mpox. Image Credit: Dotted Yeti / Shutterstock
About the study In the present study, researchers investigated whether nitroxoline, 8-hydroxyquinoline-derivative, currently used as the first-line drug therapy for urinary tract infections, could effectively combat mpox viruses. Specifically, they studied the effects of nitroxoline on the 12 mpox virus isolates, especially their replication activity, in a skin explant model.
Study findings Related StoriesIHC staining showed that nitroxoline inhibited mpox viral isolates in both skin cultures, albeit in a dose-dependent fashion. Accordingly, IC50, the antibiotic concentration that inhibited mpox virus infection by 50%, ranged between 2.4 and 4.6 µM in HFF and 0.5 and 1.5 µM in HFK, respectively.
Further, nitroxoline showed potent activity against sexually transmitted bacteria, such as Neisseria gonorrhoeae and Escherichia coli , frequently co-transmitting with the mpox virus, which could aggravate the current mpox outbreak. It also inhibited infections by two herpes viruses , HPV type 1 and varicella-zoster virus, frequently detected with mpox virus, but at >10µM concentrations, higher than what is needed to block mpox virus infection.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Study suggests a single dose of JYNNEOS vaccine may lessen the severity of mpox illnessResearchers pursued evidence that the JYNNEOS vaccine offered some protection against the mpox disease, especially they confirmed the duration for which the one dose of this vaccine conferred protection.
続きを読む »
A resilient Germany is weathering the energy crunch\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
続きを読む »
A resilient Germany is weathering the energy crunch\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
続きを読む »
Glasgow Commonwealth Games wrestler revives his old club to inspire othersSean Keogh, who competed at the 2010 games in India in both freestyle and greco-roman categories, is now looking to help the next generation achieve their dreams.
続きを読む »
Mass. Man Facing DUI Charge After Crash That Killed 22-Year-Old in Lincoln, RIA Massachusetts man was allegedly driving impaired early Saturday morning when he crashed his vehicle head-on against a barrier as he tried to enter the access portion of Route 146 in Lincoln, Rhode Island, killing one of his two passengers.
続きを読む »