An article published in GenomeBiology presents a method to simultaneously study the genetic variants, DNA methylation, GCH methyltransferase footprints, and the 3D genome in the same DNA molecule, together with the transcriptome, all in the same assay.
We developed a computational approach to improve the accuracy of our previously developed Bis-SNP method for the detection of genetic variants in bisulfite-converted reads, which can be applied to not only Methyl-HiC or NOMe-HiC but also other bisulfite sequencing data, such as WGBS, and provided a comparable genome-wide accuracy as WGS.
The future extension of NOMe-HiC together with the long-read sequencing technology to the single-cell level will eventually allow us to further characterize long-range gene-regulatory mechanisms from genetic variants to molecular phenotypes, within heterogeneous tissues.
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