“I’m always willing to take a look,” President Trump tells jonkarl when asked about medical experts recommending against the use of hydroxychloroquine to treat COVID-19.
MORE: Questions remain over whether COVID-19 recovery will guarantee immunity: Is reinfection still possible?
A randomized controlled trial is an experiment in which researchers compare half of a group that receives a new drug to half who receive a placebo. This allows researchers to accurately compare the performance of new, experimental therapies. Without a placebo group for comparison, there's no way to know for sure if a drug really makes a difference.
The authors of the JAMA paper found that additional studies on chloroquine/hydroxychloroquine, antiretrovirals, and immunoglobulin therapy were poorly designed, offered inaccurate comparisons, exposed safety concerns, or included too few patients to draw any conclusions. Beyond that, medical experts have said everyone should remain cautiously optimistic about the many COVID-19 treatments currently being tested, noting that the virus has only been known about for four months and that rigorous scientific inquiry takes time.
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