Aspergillus fumigatus is the major airborne fungus present indoors and outdoors that causes various diseases, the severity of which are dependent on an individual's immune status.
Researchers in the College of Pharmacy at the University of Tennessee Health Science Center have received a $423,500 grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health for research aimed at reducing disease and mortality rates associated with Aspergillus infections by focusing on the molecular pathways in the fungus that mediate inflammatory host responses.
Aspergillus fumigatus is a filamentous fungal pathogen that causes disease in a wide range of individuals. Most of the at-risk population have a dysfunctional immune system. In the severely immune suppressed, Aspergillus causes invasive disease that's considered highly deadly. It also causes chronic diseases in individuals who may have a hyperactive immune system.
In this collaboration between the labs of Dr. Fortwendel and Dr. Peters, the team will use a new genetic tool to identify molecular targets, or kinases, in the fungus that modify host-pathogen interactions to discover a method to assist the immune system to recognize and clear the fungus. Related StoriesAlthough the current award is focused on helping to improve outcomes for patients suffering from Aspergillus infections, the team aims to apply their studies to other fungal infections as well. With their findings, they hope to contribute to future development of novel therapeutic approaches for initiating protection from invasive fungal infections and decrease the severity of harmful host-response during chronic infections.
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